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BCR Datasheet(PDF) – Infineon Technologies AG
The Selleck dilution calculator is based on the following equation: MI is also very effective in datashfet differentiation of MLL leukemia cells and substantially increases expression of CD11b, a myeloid differentiation marker. Histone Methyltransferase Signaling Pathway Map.
Products are for research use datasheer. MI could substantially improve survival of MLL leukemic mice and does not impair normal hematopoiesis in vivo . It blocks hematologic tumors in vivo and reduces MLL leukemia tumor burden. To calculate molar mass of a chemical compound, please enter its chemical formula and click ‘Calculate’.
Chemical formula is case sensitive. Tech Support Answers to questions you may have can be found in the inhibitor handling instructions. Bio Calculators Molarity Calculator Molarity Calculator Calculate the mass, volume or concentration required for a solution. Dilution Calculator Dilution Calculator Calculate the dilution required to prepare a stock solution.
The Selleck molarity calculator is based on the following equation: Serial Dilutions Concertration start: Prolonged treatment 38 days with MI induces no toxicity in mice as reflected by no alterations in the body weight and no morphological changes in liver and kidney tissues.
MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice. The Selleck molarity calculator is based on the following equation:.
BCR Datasheet, Equivalent, Cross Reference Search. Transistor Catalog
The cell growth inhibitory effect of MI is time-dependent, with a pronounced effect achieved after days of treatment. Molecular mass molecular weight is the mass of one molecule of a substance and is expressed in the unified atomic mass units bxr. In vivo MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice.
This equation is commonly abbreviated as: It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines GI50 at nM nM rangebut only a minimal effect in human leukemia cell lines without MLL translocations. We do not sell to patients. Choose Selective Histone Methyltransferase Inhibitors.
BCR 503 E6327
Calculate the mass, volume or concentration required for a solution. Treatment with sub-micromolar concentrations of MI also leads to markedly reduced expression of Hoxa9 and Meis1, downstream targets of MLL fusion proteins substantially upregulated in MLL leukemias .
Molecular Weight Calculator Molecular Weight Calculator Enter the chemical formula of a compound to calculate its molar mass and elemental composition: These effects are accompanied by reduced c-kit CD expression, a marker associated with leukemia stem cells LSCs. For viability assays, leukemia cells are plated at relevant concentrations and treated with compounds or 0. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
References  Borkin D, et al. This is normal and is due to slight batch-to-batch variations. Not for human use. Answers to questions you may have can be found in the inhibitor handling instructions.
The Selleck dilution calculator is based on the following equation:. Menin-MLL interaction  Cell-free assay. Calculate the dilution required to prepare a stock solution.
Media is changed at day 4, viable cell numbers are restored to the original concentration and compounds are re-supplied. For cell differentiation studies, leukemia cells are treated with menin-MLL inhibitors for 7 days, then harvested, washed and incubated with Bxr Blue rat anti-mouse CD11b antibody before being analyzed by flow cytometry.